Year

2014

Type(s)

Journal Article

Author(s)

Witczak, Zbigniew J. and Sarnik, Joanna and Czubatka, Anna and Forma, Ewa and Poplawski, Tomasz

Source

Bioorganic & Medicinal Chemistry Letters, 24(24): 5606—5611, 2014

Url

http://www.sciencedirect.com/science/article/pii/S0960894X14011664

BibTeX

BibTeX

BibTeX

@article{witczak_thio-sugar_2014, title = {Thio-sugar motif of functional {CARB}-pharmacophore for antineoplastic activity. {Part} 2}, volume = {24}, issn = {0960-894X}, url = {http://www.sciencedirect.com/science/article/pii/S0960894X14011664}, doi = {10.1016/j.bmcl.2014.10.095}, abstract = {Diverse functionalized representatives of (1-4)-S-thiodisaccharides, 6–9 were synthesized and assessed for cytotoxicity and apoptosis against human cancer cell lines (A549, LoVo, MCF-7 and HeLa). The FCP 6 was more active against MCF-7 cells (i.e., an estrogen-dependent breast cancer line), whereas other (1-4)-S-thiodisaccharides showed strongest activity against A549 cells (i.e., a lung adenocarcinoma line). We propose to use a concept of functional ‘CARB-pharmacophores’ when evaluating a potential for the compounds’ general antineoplastic activity. Future studies will determine the reasons for cell-type specificity of these compounds. The thio-sugar motif appears to be a promising lead for future developments.}, number = {24}, urldate = {2015-02-26}, journal = {Bioorganic & Medicinal Chemistry Letters}, author = {Witczak, Zbigniew J. and Sarnik, Joanna and Czubatka, Anna and Forma, Ewa and Poplawski, Tomasz}, month = dec, year = {2014}, keywords = {Cancer cell lines, Thio-sugars, 1-4-S-thiodisaccharides, Functional CARB-pharmacophore (FCP)}, pages = {5606--5611}, file = {ScienceDirect Full Text PDF:C:\Users\Tomasz Poplawski\Zotero\storage\XSRCWQIH\Witczak i in. - 2014 - Thio-sugar motif of functional CARB-pharmacophore .pdf:application/pdf;ScienceDirect Snapshot:C:\Users\Tomasz Poplawski\Zotero\storage\RZ7CBKTT\S0960894X14011664.html:text/html}