Year

2017

Type(s)

Journal Article

Author(s)

Sarnik, Joanna and Czubatka-Bienkowska, Anna and Macieja, Anna and Bielski, Roman and Witczak, Zbigniew J. and Poplawski, Tomasz

Source

Bioorganic & Medicinal Chemistry Letters, 27(5): 1215—1219, 2017

BibTeX

BibTeX

BibTeX

@article{sarnik_induction_2017, title = {The induction of oxidative stress in cervix carcinoma cells by levoglucosenone derived 4-{S}-salicyl derivative and (1-4)-{S}-thio-disaccharides. {Part} 4}, volume = {27}, issn = {1464-3405}, doi = {10.1016/j.bmcl.2017.01.064}, abstract = {(1-4)-S-thiodisaccharides were shown to kill various cancer cell lines, including cervix, lung, mammary-gland and colon by unknown mechanisms. Here we identified two actions of levoglucosenone derived (1-4)-S-thiodisaccharides against cervix cancer cells: induction of oxidative stress and DNA damage. In consequence, (1-4)-S-thiodisaccharides lowered the cellular GSH level and changed the expression profile of genes encoding key proteins involved with oxidative stress response. We also observed that (1-4)-S-thiodisaccharides induced DNA damage and interfered with the thioredoxin (Trx) system. Both actions, as induced by FPC6, were stronger when dihedral angles of sulfur bridge were set to 110°, 100° and 109°, clearly indicating differences when compared to FPC8. These findings demonstrate that the 1-4-thio bridge of disaccharide is a powerful anticancer pharmacophore, and its potential use needs further studies.}, language = {eng}, number = {5}, journal = {Bioorganic & Medicinal Chemistry Letters}, author = {Sarnik, Joanna and Czubatka-Bienkowska, Anna and Macieja, Anna and Bielski, Roman and Witczak, Zbigniew J. and Poplawski, Tomasz}, year = {2017}, pmid = {28185719}, keywords = {Humans, Female, Reactive Oxygen Species, Oxidative Stress, Uterine Cervical Neoplasms, Disaccharides, Bridged Bicyclo Compounds, Heterocyclic, Glucose, DNA Damage, (1–4)-S-thiodisaccharides, Functional CARB-pharmacophore}, pages = {1215--1219}