Year

2019

Type(s)

Journal Article

Author(s)

Rozpędek, Wioletta and Pytel, Dariusz and Popławski, Tomasz and Walczak, Anna and Gradzik, Kinga and Wawrzynkiewicz, Adam and Wojtczak, Radosław and Mucha, Bartosz and Diehl, John Alan and Majsterek, Ireneusz

Source

Current Alzheimer Research, 16(3): 209—218, 2019

BibTeX

BibTeX

BibTeX

@article{rozpedek_inhibition_2019, title = {Inhibition of the {PERK}-{Dependent} {Unfolded} {Protein} {Response} {Signaling} {Pathway} {Involved} in the {Pathogenesis} of {Alzheimer}'s {Disease}}, volume = {16}, issn = {1875-5828}, doi = {10.2174/1567205016666190228121157}, abstract = {OBJECTIVES: There is a body of evidence that neurodegenerative disease entities are directly correlated with the perturbations on the molecular level. Hence, the ER stress-mediated Unfolded Protein Response (UPR) is activated resulting in PERK-dependent phosphorylation of the Eukaryotic initiation factor 2 (eIF2α). Thus, the levels of ATF4 and CHOP proteins are significantly increased, which subsequently switches the pro-adaptive branch of the UPR into the pro-apoptotic directly leading to neuronal loss and initiation of the neurodegenerative process. The aim of the presented study was the evaluation of the biological activity of highly specific, small-molecule inhibitors of the PERKdependent UPR signaling pathway. language = {eng}, number = {3}, journal = {Current Alzheimer Research}, author = {Rozpędek, Wioletta and Pytel, Dariusz and Popławski, Tomasz and Walczak, Anna and Gradzik, Kinga and Wawrzynkiewicz, Adam and Wojtczak, Radosław and Mucha, Bartosz and Diehl, John Alan and Majsterek, Ireneusz}, year = {2019}, pmid = {30819079}, keywords = {Alzheimer's disease, apoptosis, eIF2α, neurodegeneration., PERK, PERK inhibitors}, pages = {209--218}