Year

2013

Type(s)

Journal Article

Author(s)

Chojnacki, Cezary and Poplawski, Tomasz and Blasiak, Janusz and Chojnacki, Jan and Reiter, Russel J. and Klupinska, Grazyna

Source

BioMed research international, 2013: 845032, 2013

BibTeX

BibTeX

BibTeX

@article{chojnacki_expression_2013, title = {Expression of melatonin synthesizing enzymes in {Helicobacter} pylori infected gastric mucosa.}, volume = {2013}, issn = {2314-6141}, doi = {10.1155/2013/845032}, abstract = {Helicobacter pylori colonization of gastric mucosa causes pain of unknown etiology in about 15-20% of infected subjects. The aim of the present work was to determine the level of expression of enzymes involved in the synthesis of melatonin in gastric mucosa of asymptomatic and symptomatic H. pylori infected patients. To diagnose H. pylori infection, histological analysis and the urea breath test (UBT C13) were performed. The levels of mRNA expression of arylalkylamine-N-acetyltransferase (AA-NAT) and acetylserotonin methyltransferase (ASMT) were estimated in gastric mucosa with RT-PCR. The level of AA-NAT expression and AMST was decreased in H. pylori infected patients and was increased after H. pylori eradication. We conclude that decreased expression of melatonin synthesizing enzymes, AA-NAT and ASMT, in patients with symptomatic H. pylori infection returns to normal level after H. pylori eradication.}, journal = {BioMed research international}, author = {Chojnacki, Cezary and Poplawski, Tomasz and Blasiak, Janusz and Chojnacki, Jan and Reiter, Russel J. and Klupinska, Grazyna}, month = jul, year = {2013}, note = {MEDLINE:23936850}, pages = {845032}