Year

2009

Type(s)

Journal Article

Author(s)

Wozniak, Katarzyna and Szaflik, Jacek P. and Zaras, Malgorzata and Sklodowska, Anna and Janik-Papis, Katarzyna and Poplawski, Tomasz R. and Blasiak, Janusz and Szaflik, Jerzy

Source

Journal of Biomedicine & Biotechnology, 2009: 827562, 2009

BibTeX

BibTeX

BibTeX

@article{wozniak_dna_2009, title = {{DNA} damage/repair and polymorphism of the {hOGG}1 gene in lymphocytes of {AMD} patients}, volume = {2009}, issn = {1110-7251}, doi = {10.1155/2009/827562}, abstract = {Oxidative stress is thought to play a role in the pathogenesis of age-related macular degeneration (AMD). We determined the extent of oxidative DNA damage and the kinetics of its removal as well as the genotypes of the Ser326Cys polymorphism of the hOGG1 gene in lymphocytes of 30 wet AMD patients and 30 controls. Oxidative DNA damage induced by hydrogen peroxide and its repair were evaluated by the comet assay and DNA repair enzymes. We observed a higher extent of endogenous oxidative DNA damage and a lower efficacy of its repair in AMD patients as compared with the controls. We did not find any correlation between the extent of DNA damage and efficacy of DNA repair with genotypes of the Ser326Cys polymorphism. The results obtained suggest that oxidative DNA damage and inefficient DNA repair can be associated with AMD and the variability of the hOOG1 gene may not contribute to this association.}, language = {eng}, journal = {Journal of Biomedicine & Biotechnology}, author = {Wozniak, Katarzyna and Szaflik, Jacek P. and Zaras, Malgorzata and Sklodowska, Anna and Janik-Papis, Katarzyna and Poplawski, Tomasz R. and Blasiak, Janusz and Szaflik, Jerzy}, year = {2009}, pmid = {19885394}, pmcid = {PMC2766933}, keywords = {Humans, Case-Control Studies, DNA Repair, DNA, DNA Glycosylases, Hydrogen Peroxide, Lymphocytes, Polymorphism, Genetic, Gene Frequency, Macular Degeneration, Oxidative Stress, DNA Damage}, pages = {827562}