Tomasz Poplawski
Professor @ University of Lodz
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A potential CARB-pharmacophore for antineoplastic activity: part 1
Publications
Year
2014
Type(s)
Journal Article
Author(s)
Witczak, Zbigniew J. and Poplawski, Tomasz and Czubatka, Anna and Sarnik, Joanna and Tokarz, Pawel and VanWert, Adam L. and Bielski, Roman
Source
Bioorganic & Medicinal Chemistry Letters, 24(7): 1752—1757, 2014
BibTeX
BibTeX
BibTeX
@article{witczak_potential_2014, title = {A potential {CARB}-pharmacophore for antineoplastic activity: part 1}, volume = {24}, issn = {1464-3405}, shorttitle = {A potential {CARB}-pharmacophore for antineoplastic activity}, doi = {10.1016/j.bmcl.2014.02.036}, abstract = {Diverse functionalized representatives of various classes of sugars, such as thio-, anhydro-, and sulfamido-sugars and myo-inositol oxide, were synthesized and assessed for cytotoxicity against human cancer cell lines (A549, LoVo, MCF-7 and HeLa). The inositol oxide (4) was more active against MCF-7 cells (i.e., an estrogen-dependent breast cancer line), whereas all 3 sulfur-containing compounds showed strongest activity against A549 cells (i.e., a lung adenocarcinoma line). We propose to use a concept of functional 'CARB-pharmacophores' when evaluating a potential for the compounds' general antineoplastic activity. Future studies will determine the reasons for cell-type specificity of these compounds. The thio-sugar motif appears to be a promising lead for future developments.}, language = {eng}, number = {7}, journal = {Bioorganic & Medicinal Chemistry Letters}, author = {Witczak, Zbigniew J. and Poplawski, Tomasz and Czubatka, Anna and Sarnik, Joanna and Tokarz, Pawel and VanWert, Adam L. and Bielski, Roman}, month = apr, year = {2014}, pmid = {24602905}, pages = {1752--1757}