Year

2014

Type(s)

Journal Article

Author(s)

Witczak, Zbigniew J. and Poplawski, Tomasz and Czubatka, Anna and Sarnik, Joanna and Tokarz, Pawel and VanWert, Adam L. and Bielski, Roman

Source

Bioorganic & Medicinal Chemistry Letters, 24(7): 1752—1757, 2014

BibTeX

BibTeX

BibTeX

@article{witczak_potential_2014, title = {A potential {CARB}-pharmacophore for antineoplastic activity: part 1}, volume = {24}, issn = {1464-3405}, shorttitle = {A potential {CARB}-pharmacophore for antineoplastic activity}, doi = {10.1016/j.bmcl.2014.02.036}, abstract = {Diverse functionalized representatives of various classes of sugars, such as thio-, anhydro-, and sulfamido-sugars and myo-inositol oxide, were synthesized and assessed for cytotoxicity against human cancer cell lines (A549, LoVo, MCF-7 and HeLa). The inositol oxide (4) was more active against MCF-7 cells (i.e., an estrogen-dependent breast cancer line), whereas all 3 sulfur-containing compounds showed strongest activity against A549 cells (i.e., a lung adenocarcinoma line). We propose to use a concept of functional 'CARB-pharmacophores' when evaluating a potential for the compounds' general antineoplastic activity. Future studies will determine the reasons for cell-type specificity of these compounds. The thio-sugar motif appears to be a promising lead for future developments.}, language = {eng}, number = {7}, journal = {Bioorganic & Medicinal Chemistry Letters}, author = {Witczak, Zbigniew J. and Poplawski, Tomasz and Czubatka, Anna and Sarnik, Joanna and Tokarz, Pawel and VanWert, Adam L. and Bielski, Roman}, month = apr, year = {2014}, pmid = {24602905}, pages = {1752--1757}